Ontology highlight
ABSTRACT:
SUBMITTER: Gaponova AV
PROVIDER: S-EPMC5386675 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Gaponova Anna V AV Deneka Alexander Y AY Beck Tim N TN Liu Hanqing H Andrianov Gregory G Nikonova Anna S AS Nicolas Emmanuelle E Einarson Margret B MB Golemis Erica A EA Serebriiskii Ilya G IG
Oncotarget 20170301 12
Ovarian, head and neck, and other cancers are commonly treated with cisplatin and other DNA damaging cytotoxic agents. Altered DNA damage response (DDR) contributes to resistance of these tumors to chemotherapies, some targeted therapies, and radiation. DDR involves multiple protein complexes and signaling pathways, some of which are evolutionarily ancient and involve protein orthologs conserved from yeast to humans. To identify new regulators of cisplatin-resistance in human tumors, we integrat ...[more]