Ontology highlight
ABSTRACT:
SUBMITTER: Ziani L
PROVIDER: S-EPMC5386721 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Ziani Linda L Safta-Saadoun Thouraya Ben TB Gourbeix Johanne J Cavalcanti Andrea A Robert Caroline C Favre Gilles G Chouaib Salem S Thiery Jerome J
Oncotarget 20170301 12
Cancer-associated fibroblasts (CAFs) play a central role in the complex process of tumor-stroma interaction and promote tumor growth. Emerging evidences also suggest that these fibroblasts are involved in the alteration of the anti-tumor immune response by impacting several immune cell populations, especially through their secretion of pro-inflammatory and immunosuppressive factors in the tumor microenvironment. However, the underlying immuno-modulating mechanisms triggered by these fibroblasts ...[more]