Ontology highlight
ABSTRACT:
SUBMITTER: Balsamo M
PROVIDER: S-EPMC2791633 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Balsamo Mirna M Scordamaglia Francesca F Pietra Gabriella G Manzini Claudia C Cantoni Claudia C Boitano Monica M Queirolo Paola P Vermi William W Facchetti Fabio F Moretta Alessandro A Moretta Lorenzo L Mingari Maria Cristina MC Vitale Massimo M
Proceedings of the National Academy of Sciences of the United States of America 20091123 49
Although the role of the tumor microenvironment in the process of cancer progression has been extensively investigated, the contribution of different stromal components to tumor growth and/or evasion from immune surveillance is still only partially defined. In this study we analyzed fibroblasts derived from metastatic melanomas and provide evidence for their strong immunosuppressive activity. In coculture experiments, melanoma-derived fibroblasts sharply interfered with NK cell functions includi ...[more]