Plasma Epstein-Barr virus DNA for pediatric Burkitt lymphoma diagnosis, prognosis and response assessment in Malawi.
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ABSTRACT:
SUBMITTER: Westmoreland KD
PROVIDER: S-EPMC5386821 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Plasma Epstein-Barr virus DNA for pediatric Burkitt lymphoma diagnosis, prognosis and response assessment in Malawi.
Westmoreland Katherine D KD Montgomery Nathan D ND Stanley Christopher C CC El-Mallawany Nader Kim NK Wasswa Peter P van der Gronde Toon T Mtete Idah I Butia Mercy M Itimu Salama S Chasela Mary M Mtunda Mary M Kampani Coxcilly C Liomba N George NG Tomoka Tamiwe T Dhungel Bal M BM Sanders Marcia K MK Krysiak Robert R Kazembe Peter P Dittmer Dirk P DP Fedoriw Yuri Y Gopal Satish S
International journal of cancer 20170324 11
Point-of-care tools are needed in sub-Saharan Africa (SSA) to improve pediatric Burkitt lymphoma (BL) diagnosis and treatment. We evaluated plasma Epstein-Barr virus (pEBV) DNA as a pediatric BL biomarker in Malawi. Prospectively enrolled children with BL were compared to classical Hodgkin lymphoma (cHL) and nonlymphoma diagnoses. Pediatric BL patients received standardized chemotherapy and supportive care. pEBV DNA was measured at baseline, mid-treatment, and treatment completion. Of 121 assess ...[more]
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