Dataset Information

Complete manuscript Title: Changes in RANKL during the first two years after cART initiation in HIV-infected cART naive adults.

ABSTRACT:

Background

By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery.

Methods

We used multiplex immunoassays to determine sRANKL and OPG concentrations in plasma from 48 HIV patients at baseline and 12, 24, 48 and 96 weeks after cART initiation.

Results

Soluble RANKL changed significantly over time (overall p = 0.02) with 25% decrease (95% CI: -42 to -5) at week 24 compared to baseline and stabilized at a lower level thereafter. We found no correlation between CD4+ T cell count increment and changes in sRANKL or between percentage change in BMD and changes in sRANKL.

Conclusion

In this study there was no indication that the accelerated bone loss after cART initiation was mediated by early changes in sRANKL due to CD4+ T cell recovery. Future studies should focus on the initial weeks after initiation of cART.

Trial registration

Clinical-Trial.gov . id NCT00135460 , August 25, 2005. The study was approved by the Danish Data Protection Agency, Danish Medicines Agency and Regional Ethics Committee.

SUBMITTER: Mathiesen IH

PROVIDER: S-EPMC5387326 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Publications

Complete manuscript Title: Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults.

Mathiesen Inger Hee IH Salem Mohammad M Gerstoft Jan J Gaardbo Julie Christine JC Obel Niels N Pedersen Court C Ullum Henrik H Nielsen Susanne Dam SD Hansen Ann-Brit Eg AE

BMC infectious diseases 20170411 1

<h4>Background</h4>By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery.<h4>Methods</h4>We used multiplex immunoassays to determine sRANKL and OPG concentr ...[more]

PMID: 28399815

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