Ontology highlight
ABSTRACT:
SUBMITTER: Mathiesen IH
PROVIDER: S-EPMC5387326 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mathiesen Inger Hee IH Salem Mohammad M Gerstoft Jan J Gaardbo Julie Christine JC Obel Niels N Pedersen Court C Ullum Henrik H Nielsen Susanne Dam SD Hansen Ann-Brit Eg AE
BMC infectious diseases 20170411 1
<h4>Background</h4>By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery.<h4>Methods</h4>We used multiplex immunoassays to determine sRANKL and OPG concentr ...[more]