Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5388401 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Yang Jennifer J Tanaka Yoshiaki Y Seay Montrell M Li Zhen Z Jin Jiaqi J Garmire Lana Xia LX Zhu Xun X Taylor Ashley A Li Weidong W Euskirchen Ghia G Halene Stephanie S Kluger Yuval Y Snyder Michael P MP Park In-Hyun IH Pan Xinghua X Weissman Sherman Morton SM
Nucleic acids research 20170201 3
Molecular changes underlying stem cell differentiation are of fundamental interest. scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 separated the cells into 3 main clusters with distinct features: active, quiescent, and an un-characterized cluster. Induction of anemia resulted in mobilization of the quiescent to the active cluster and of the early to later stage of cell cycle, with marked increase in expression of certain transcription factors (TFs) while maintaining ex ...[more]