Ontology highlight
ABSTRACT:
SUBMITTER: Chaliotis A
PROVIDER: S-EPMC5388404 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Chaliotis Anargyros A Vlastaridis Panayotis P Mossialos Dimitris D Ibba Michael M Becker Hubert D HD Stathopoulos Constantinos C Amoutzias Grigorios D GD
Nucleic acids research 20170201 3
Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes responsible for the faithful translation of the genetic code and have lately become a prominent target for synthetic biologists. Our large-scale analysis of >2500 prokaryotic genomes reveals the complex evolutionary history of these enzymes and their paralogs, in which horizontal gene transfer played an important role. These results show that a widespread belief in the evolutionary stability of this superfamily is misconceived. Alth ...[more]