Ontology highlight
ABSTRACT:
SUBMITTER: Borgel J
PROVIDER: S-EPMC5388433 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Borgel Julie J Tyl Marek M Schiller Karin K Pusztai Zsofia Z Dooley Christopher M CM Deng Wen W Wooding Carol C White Richard J RJ Warnecke Tobias T Leonhardt Heinrich H Busch-Nentwich Elisabeth M EM Bartke Till T
Nucleic acids research 20170201 3
Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their biological function is largely unknown. Here we provide a detailed molecular analysis of chromatin recognition by the lysine demethylase KDM2A. Using biochemical approaches we identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD do ...[more]