Ontology highlight
ABSTRACT:
SUBMITTER: Kikani CK
PROVIDER: S-EPMC5035144 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kikani Chintan K CK Wu Xiaoying X Paul Litty L Sabic Hana H Shen Zuolian Z Shakya Arvind A Keefe Alexandra A Villanueva Claudio C Kardon Gabrielle G Graves Barbara B Tantin Dean D Rutter Jared J
eLife 20160923
PAS domain containing protein kinase (Pask) is an evolutionarily conserved protein kinase implicated in energy homeostasis and metabolic regulation across eukaryotic species. We now describe an unexpected role of Pask in promoting the differentiation of myogenic progenitor cells, embryonic stem cells and adipogenic progenitor cells. This function of Pask is dependent upon its ability to phosphorylate Wdr5, a member of several protein complexes including those that catalyze histone H3 Lysine 4 tr ...[more]