Ontology highlight
ABSTRACT:
SUBMITTER: Richner JM
PROVIDER: S-EPMC5388441 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Richner Justin M JM Himansu Sunny S Dowd Kimberly A KA Butler Scott L SL Salazar Vanessa V Fox Julie M JM Julander Justin G JG Tang William W WW Shresta Sujan S Pierson Theodore C TC Ciaramella Giuseppe G Diamond Michael S MS
Cell 20170217 6
The emergence of ZIKV infection has prompted a global effort to develop safe and effective vaccines. We engineered a lipid nanoparticle (LNP) encapsulated modified mRNA vaccine encoding wild-type or variant ZIKV structural genes and tested immunogenicity and protection in mice. Two doses of modified mRNA LNPs encoding prM-E genes that produced virus-like particles resulted in high neutralizing antibody titers (∼1/100,000) that protected against ZIKV infection and conferred sterilizing immunity. ...[more]