Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease.
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ABSTRACT:
SUBMITTER: Meyer M
PROVIDER: S-EPMC5853918 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease.
Meyer Michelle M Huang Eric E Yuzhakov Olga O Ramanathan Palaniappan P Ciaramella Giuseppe G Bukreyev Alexander A
The Journal of infectious diseases 20180101 3
Most current Ebola virus (EBOV) vaccine candidates are based on viral vectors, some of which cause side effects or require complex manufacturing. Modified mRNA vaccines are easily produced, safe, and are highly immunogenic. We developed 2 mRNA vaccines based on the EBOV envelope glycoprotein, which differed by the nature of signal peptide for improved glycoprotein post-translational translocation. The mRNAs were formulated with lipid nanoparticles to facilitate delivery. Vaccination of guinea pi ...[more]
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