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DfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.

ABSTRACT: A novel trimethoprim resistance gene, designated dfrA20, was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. The dfrA20 gene codes for a dihydrofolate reductase of 169 amino acids. Sequence comparisons revealed that the DfrA20 protein differed distinctly from all dihydrofolate reductases known so far.

SUBMITTER: Kehrenberg C

PROVIDER: S-EPMC538868 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature

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dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.

Kehrenberg Corinna C Schwarz Stefan S

Antimicrobial agents and chemotherapy 20050101 1

A novel trimethoprim resistance gene, designated dfrA20, was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. The dfrA20 gene codes for a dihydrofolate reductase of 169 amino acids. Sequence comparisons revealed that the DfrA20 protein differed distinctly from all dihydrofolate reductases known so far. ...[more]

PMID: 15616323

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