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Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.

ABSTRACT: Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leucine and Gly83 was replaced with arginine.

SUBMITTER: Conrads G

PROVIDER: S-EPMC538909 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature

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Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.

Conrads Georg G Citron Diane M DM Goldstein Ellie J C EJ

Antimicrobial agents and chemotherapy 20050101 1

Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leuci ...[more]

PMID: 15616329

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