Ontology highlight
ABSTRACT:
SUBMITTER: Vullo S
PROVIDER: S-EPMC5389290 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170320 14
Acid-sensing ion channels (ASICs) are proton-activated Na<sup>+</sup> channels expressed in the nervous system, where they are involved in learning, fear behaviors, neurodegeneration, and pain sensation. In this work, we study the role in pH sensing of two regions of the ectodomain enriched in acidic residues: the acidic pocket, which faces the outside of the protein and is the binding site of several animal toxins, and the palm, a central channel domain. Using voltage clamp fluorometry, we find ...[more]