Ontology highlight
ABSTRACT:
SUBMITTER: Telonis AG
PROVIDER: S-EPMC5389567 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Telonis Aristeidis G AG Magee Rogan R Loher Phillipe P Chervoneva Inna I Londin Eric E Rigoutsos Isidore I
Nucleic acids research 20170401 6
Isoforms of human miRNAs (isomiRs) are constitutively expressed with tissue- and disease-subtype-dependencies. We studied 10 271 tumor datasets from The Cancer Genome Atlas (TCGA) to evaluate whether isomiRs can distinguish amongst 32 TCGA cancers. Unlike previous approaches, we built a classifier that relied solely on 'binarized' isomiR profiles: each isomiR is simply labeled as 'present' or 'absent'. The resulting classifier successfully labeled tumor datasets with an average sensitivity of 90 ...[more]