Ontology highlight
ABSTRACT:
SUBMITTER: Bofill-De Ros X
PROVIDER: S-EPMC6776719 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bofill-De Ros Xavier X Yang Acong A Gu Shuo S
Biochimica et biophysica acta. Gene regulatory mechanisms 20190404 4
MicroRNAs (miRNAs) are a class of small non-coding RNAs that play increasingly appreciated roles in gene regulation. In animals, miRNAs silence gene expression by binding to partially complementary sequences within target mRNAs. It is well-established that miRNAs recognize canonical target sites by base-pairing in the 5'region. However, the development of biochemical methods has identified many novel, non-canonical target sites, suggesting additional modes of miRNA-target association. Here, we r ...[more]