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Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia.


ABSTRACT:

Objective

The aim of this study was to analyze the clinicopathologic characteristics and prognosis of signet ring cell carcinoma (SRC) according to disease status (early vs advanced gastric cancer) in gastric cancer patients.

Background

The prognostic implication of gastric SRC remains a subject of debate.

Methods

A retrospective analysis was performed using the clinical records of 7667 patients including 1646 SRC patients who underwent radical gastrectomy between 2001 and 2010. A further analysis was also performed after dividing patients into three groups according to histologic subtype: SRC, well-to-moderately differentiated (WMD), and poorly differentiated adenocarcinoma.

Results

SRC patients have younger age distribution and female predominance compared with other histologic subtypes. Notably, the distribution of T stage of SRC patients was distinct, located in extremes (T1: 66.2% and T4: 20%). Moreover, the prognosis of SRC in early gastric cancer and advanced gastric cancer was contrasting. In early gastric cancer, SRC demonstrated more favorable prognosis than WMD after adjusting for age, sex, and stage. In contrast, SRC in advanced gastric cancer displayed worse prognosis than WMD. As stage increased, survival outcomes of SRC continued to worsen compared with WMD.

Conclusions

Although conferring favorable prognosis in early stage, SRC has worse prognostic impact as disease progresses. The longstanding controversy of SRC on prognosis may result from disease status at presentation, which leads to differing prognosis compared with tubular adenocarinoma.

SUBMITTER: Chon HJ 

PROVIDER: S-EPMC5389602 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Publications

Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia.

Chon Hong Jae HJ   Hyung Woo Jin WJ   Kim Chan C   Park Sohee S   Kim Jie-Hyun JH   Park Chan Hyuk CH   Ahn Joong Bae JB   Kim Hyunki H   Chung Hyun Cheol HC   Rha Sun Young SY   Noh Sung Hoon SH   Jeung Hei-Cheul HC  

Annals of surgery 20170501 5


<h4>Objective</h4>The aim of this study was to analyze the clinicopathologic characteristics and prognosis of signet ring cell carcinoma (SRC) according to disease status (early vs advanced gastric cancer) in gastric cancer patients.<h4>Background</h4>The prognostic implication of gastric SRC remains a subject of debate.<h4>Methods</h4>A retrospective analysis was performed using the clinical records of 7667 patients including 1646 SRC patients who underwent radical gastrectomy between 2001 and  ...[more]

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