Ontology highlight
ABSTRACT:
SUBMITTER: Han W
PROVIDER: S-EPMC5389615 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Han Wenyuan W Li Yingjun Y Deng Ling L Feng Mingxia M Peng Wenfang W Hallstrøm Søren S Zhang Jing J Peng Nan N Liang Yun Xiang YX White Malcolm F MF She Qunxin Q
Nucleic acids research 20170201 4
The CRISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteria by eliminating nucleic acid invaders in a crRNA-guided manner. The Sulfolobus islandicus type III-B Cmr-α system targets invading nucleic acid at both RNA and DNA levels and DNA targeting relies on the directional transcription of the protospacer in vivo. To gain further insight into the involved mechanism, we purified a native effector complex of III-B Cmr-α from S. islandicus and charact ...[more]