Ontology highlight
ABSTRACT:
SUBMITTER: Vlot M
PROVIDER: S-EPMC5778469 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Vlot Marnix M Houkes Joep J Lochs Silke J A SJA Swarts Daan C DC Zheng Peiyuan P Kunne Tim T Mohanraju Prarthana P Anders Carolin C Jinek Martin M van der Oost John J Dickman Mark J MJ Brouns Stan J J SJJ
Nucleic acids research 20180101 2
Prokaryotes encode various host defense systems that provide protection against mobile genetic elements. Restriction-modification (R-M) and CRISPR-Cas systems mediate host defense by sequence specific targeting of invasive DNA. T-even bacteriophages employ covalent modifications of nucleobases to avoid binding and therefore cleavage of their DNA by restriction endonucleases. Here, we describe that DNA glucosylation of bacteriophage genomes affects interference of some but not all CRISPR-Cas syst ...[more]