Ontology highlight
ABSTRACT:
SUBMITTER: Vandervelde A
PROVIDER: S-EPMC5389731 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20170401 6
Bacteria can become transiently tolerant to several classes of antibiotics. This phenomenon known as persistence is regulated by small genetic elements called toxin-antitoxin modules with intricate yet often poorly understood self-regulatory features. Here, we describe the structures of molecular complexes and interactions that drive the transcription regulation of the ccdAB toxin-antitoxin module. Low specificity and affinity of the antitoxin CcdA2 for individual binding sites on the operator a ...[more]