Ontology highlight
ABSTRACT:
SUBMITTER: Mohr S
PROVIDER: S-EPMC5389883 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mohr Sebastian S Doebele Carmen C Comoglio Federico F Berg Tobias T Beck Julia J Bohnenberger Hanibal H Alexe Gabriela G Corso Jasmin J Ströbel Philipp P Wachter Astrid A Beissbarth Tim T Schnütgen Frank F Cremer Anjali A Haetscher Nadine N Göllner Stefanie S Rouhi Arefeh A Palmqvist Lars L Rieger Michael A MA Schroeder Timm T Bönig Halvard H Müller-Tidow Carsten C Kuchenbauer Florian F Schütz Ekkehard E Green Anthony R AR Urlaub Henning H Stegmaier Kimberly K Humphries R Keith RK Serve Hubert H Oellerich Thomas T
Cancer cell 20170401 4
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic analysis revealed that Meis1 increased Syk protein expression and activity. Syk upregulation occurs through a Meis1-dependent feedback loop. By dissecting this loop, we show that Sy ...[more]