Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5390057 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Li Jingchen J Jiang Hongyuan H
Biophysical journal 20170401 7
Proper organelle size is critical for many cell functions. However, how cells sense and control their organelle size remains elusive. Here, we develop a general model to study the size control of mitotic spindles by considering both extrinsic and intrinsic factors, such as the limited number of building blocks of the spindle, the interaction between the spindle and cell boundary, the DNA content, the forces generated by various molecular motors, and the dynamics of microtubules. We show that mul ...[more]