Ontology highlight
ABSTRACT:
SUBMITTER: Xia X
PROVIDER: S-EPMC4614068 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Xia Xiaoyu X Gholkar Ankur A Senese Silvia S Torres Jorge Z JZ
Cell cycle (Georgetown, Tex.) 20150101 12
Leucine carboxyl methyltransferase-1 (LCMT1) and protein phosphatase methylesterase-1 (PME-1) are essential enzymes that regulate the methylation of the protein phosphatase 2A catalytic subunit (PP2AC). LCMT1 and PME-1 have been linked to the regulation of cell growth and proliferation, but the underlying mechanisms have remained elusive. We show here an important role for an LCMT1-PME-1 methylation equilibrium in controlling mitotic spindle size. Depletion of LCMT1 or overexpression of PME-1 le ...[more]