Ontology highlight
ABSTRACT:
SUBMITTER: Kruitwagen HS
PROVIDER: S-EPMC5390114 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Kruitwagen Hedwig S HS Oosterhoff Loes A LA Vernooij Ingrid G W H IGWH Schrall Ingrid M IM van Wolferen Monique E ME Bannink Farah F Roesch Camille C van Uden Lisa L Molenaar Martijn R MR Helms J Bernd JB Grinwis Guy C M GCM Verstegen Monique M A MMA van der Laan Luc J W LJW Huch Meritxell M Geijsen Niels N Vries Robert G RG Clevers Hans H Rothuizen Jan J Schotanus Baukje A BA Penning Louis C LC Spee Bart B
Stem cell reports 20170323 4
Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the potential of liver organoids for modeling genetic diseases. To examine the possibility of using organoids to model steatosis, we established a long-term feline liver organoid culture with adult liver stem cell characteristics and differentiation potential towa ...[more]