Complete fold annotation of the human proteome using a novel structural feature space.
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ABSTRACT:
SUBMITTER: Middleton SA
PROVIDER: S-EPMC5390313 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Complete fold annotation of the human proteome using a novel structural feature space.
Middleton Sarah A SA Illuminati Joseph J Kim Junhyong J
Scientific reports 20170413
Recognition of protein structural fold is the starting point for many structure prediction tools and protein function inference. Fold prediction is computationally demanding and recognizing novel folds is difficult such that the majority of proteins have not been annotated for fold classification. Here we describe a new machine learning approach using a novel feature space that can be used for accurate recognition of all 1,221 currently known folds and inference of unknown novel folds. We show t ...[more]
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