Ontology highlight
ABSTRACT:
SUBMITTER: Fischer T
PROVIDER: S-EPMC5390795 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Fischer Thomas T Riedl Rainer R
ChemistryOpen 20170112 2
The incorporation of fluorine atoms into functional molecules is of wide interest in synthetic organic chemistry as well as cognate disciplines. In particular, in medicinal chemistry, there is a strong desire to positively influence the physicochemical molecular properties of drug compounds by introducing fluorine into biologically active molecules. Here, we present targeted fluoro positioning as the key design principle of converting a weak matrix metalloproteinase-13 (MMP-13) inhibitor into a ...[more]