Ontology highlight
ABSTRACT:
SUBMITTER: Abdullah L
PROVIDER: S-EPMC5391242 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Abdullah Laila L Evans James E JE Emmerich Tanja T Crynen Gogce G Shackleton Ben B Keegan Andrew P AP Luis Cheryl C Tai Leon L LaDu Mary J MJ Mullan Michael M Crawford Fiona F Bachmeier Corbin C
Aging 20170301 3
This study was designed to explore the influence of apolipoprotein E (APOE) on blood phospholipids (PL) in predicting preclinical Alzheimer's disease (AD). Lipidomic analyses were also performed on blood from an AD mouse model expressing human APOE isoforms (EFAD) and five AD mutations and from 195 cognitively normal participants, 23 of who converted to mild cognitive impairment (MCI)/AD within 3 years. APOE ε4-carriers converting to MCI/AD had high arachidonic acid (AA)/docosahexaenoic acid (DH ...[more]