Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects.

ABSTRACT:

Purpose

The purpose of this work was to explore the impact of slice profile effects on apparent diffusion coefficient (ADC) mapping of hyperpolarized (HP) substrates.

Methods

Slice profile effects were simulated using a Gaussian radiofrequency (RF) pulse with a variety of flip angle schedules and b-value ordering schemes. A long T₁ water phantom was used to validate the simulation results, and ADC mapping of HP [¹³ C,¹⁵ N₂ ]urea was performed on the murine liver to assess these effects in vivo.

Results

Slice profile effects result in excess signal after repeated RF pulses, causing bias in HP measurements. The largest error occurs for metabolites with small ADCs, resulting in up to 10-fold overestimation for metabolites that

SUBMITTER: Gordon JW 

PROVIDER: S-EPMC5391314 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature