Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcinoma population.

ABSTRACT:

Background

To better understand the associations between a history of tobacco use and survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated patients with cancer of the oral cavity (n = 271), oropharynx (n = 257), larynx (n = 135), or hypopharynx (n = 24).

Methods

Kaplan-Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS).

Results

Cigarette use duration, timing, and intensity were significant predictors for all outcomes in univariate analysis. Never smoking and pack-years were not significantly associated with outcomes after adjustment for prognostic factor

SUBMITTER: Peterson LA 

PROVIDER: S-EPMC5391974 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature