Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.
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ABSTRACT:
SUBMITTER: Kaufman SK
PROVIDER: S-EPMC5392364 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
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Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.
Kaufman Sarah K SK Sanders David W DW Thomas Talitha L TL Ruchinskas Allison J AJ Vaquer-Alicea Jaime J Sharma Apurwa M AM Miller Timothy M TM Diamond Marc I MI
Neuron 20161027 4
Tauopathies are neurodegenerative disorders that affect distinct brain regions, progress at different rates, and exhibit specific patterns of tau accumulation. The source of this diversity is unknown. We previously characterized two tau strains that stably maintain unique conformations in vitro and in vivo, but did not determine the relationship of each strain to parameters that discriminate between tauopathies such as regional vulnerability or rate of spread. We have now isolated and characteri ...[more]
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