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Hepatitis E in Singapore: A Case-Series and Viral Phylodynamics Study.


ABSTRACT: AbstractThe incidence of hepatitis E in Singapore appears to be increasing. A retrospective case-series study of patients diagnosed with hepatitis E in a tertiary hospital from 2009 to 2013 was conducted. Of 16 cases, eight (50%) were solid-organ transplant recipients (SOTRs), and 14 (88%) were found infected by genotype 3 hepatitis E virus (HEV-3). Bayesian inferences based on HEV subgenomic sequences from seven cases suggest that HEV-3 strains were introduced to Singapore as two principal lineages. Within limitations of the study, it can be inferred that one lineage, in the 3efg clade, emerged about 83 years ago, probably originating from Japan, whereas the other, in the 3abchij clade, emerged about 40 years ago, from the United States. Establishment and subsequent transmissions of strains from these two lineages likely contribute to the current endemicity of hepatitis E in Singapore.

SUBMITTER: Teo EC 

PROVIDER: S-EPMC5392643 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Hepatitis E in Singapore: A Case-Series and Viral Phylodynamics Study.

Teo Esmeralda Chi-Yuan EC   Tan Boon-Huan BH   Purdy Michael A MA   Wong Pui-San PS   Ting Pei-Jun PJ   Chang Pik-Eu Jason PJ   Oon Lynette Lin-Ean LL   Sue Amanda A   Teo Chong-Gee CG   Tan Chee-Kiat CK  

The American journal of tropical medicine and hygiene 20170116 4


AbstractThe incidence of hepatitis E in Singapore appears to be increasing. A retrospective case-series study of patients diagnosed with hepatitis E in a tertiary hospital from 2009 to 2013 was conducted. Of 16 cases, eight (50%) were solid-organ transplant recipients (SOTRs), and 14 (88%) were found infected by genotype 3 hepatitis E virus (HEV-3). Bayesian inferences based on HEV subgenomic sequences from seven cases suggest that HEV-3 strains were introduced to Singapore as two principal line  ...[more]

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