Ontology highlight
ABSTRACT:
SUBMITTER: Tamayo JV
PROVIDER: S-EPMC5392723 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cell reports 20170401 1
The Drosophila hnRNP F/H homolog, Glorund (Glo), regulates nanos mRNA translation by interacting with a structured UA-rich motif in the nanos 3' untranslated region. Glo regulates additional RNAs, however, and mammalian homologs bind G-tract sequences to regulate alternative splicing, suggesting that Glo also recognizes G-tract RNA. To gain insight into how Glo recognizes both structured UA-rich and G-tract RNAs, we used mutational analysis guided by crystal structures of Glo's RNA-binding domai ...[more]