Ontology highlight
ABSTRACT:
SUBMITTER: Eser U
PROVIDER: S-EPMC5393236 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Eser Umut U Chandler-Brown Devon D Ay Ferhat F Straight Aaron F AF Duan Zhijun Z Noble William Stafford WS Skotheim Jan M JM
Proceedings of the National Academy of Sciences of the United States of America 20170327 15
The genome of metazoan cells is organized into topologically associating domains (TADs) that have similar histone modifications, transcription level, and DNA replication timing. Although similar structures appear to be conserved in fission yeast, computational modeling and analysis of high-throughput chromosome conformation capture (Hi-C) data have been used to argue that the small, highly constrained budding yeast chromosomes could not have these structures. In contrast, herein we analyze Hi-C ...[more]