Acute peripheral metabolic effects of intraarterial ghrelin infusion in healthy young men.

ABSTRACT:

Context

Ghrelin is the endogenous agonist for the growth hormone secretagogue receptor (GHS-R). Intravenous administration of ghrelin induces insulin resistance and hyperglycemia and increases the levels of free fatty acids (FFA).

Objective

To investigate whether these effects are mediated directly by ghrelin in skeletal muscle tissue.

Design

This study was single blinded, randomized, and placebo controlled. Eight healthy men (25.5 ± 3.1 years) received 240 min of intraarterial ghrelin infusion (4.2 ng × kg(-1) × min(-1)) into one femoral artery and intraarterial placebo infusion into the contralateral artery. Simultaneous blood samples were drawn from both femoral veins and muscle biopsies were obtained from both legs during both a basal period and during a hyperinsu

SUBMITTER: Vestergaard ET 

PROVIDER: S-EPMC5393419 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature