Ontology highlight
ABSTRACT:
SUBMITTER: Shetty A
PROVIDER: S-EPMC5394798 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Shetty Ameet A Kallgren Scott P SP Demel Carina C Maier Kerstin C KC Spatt Dan D Alver Burak H BH Cramer Patrick P Park Peter J PJ Winston Fred F
Molecular cell 20170330 1
Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood. We have analyzed the consequences of Spt5 depletion in Schizosaccharomyces pombe using four genome-wide approaches. Our results demonstrate that Spt5 is crucial for a normal rate of RNA synthesis and distribution of RNAPII over transcription units. In the absence of Spt5, RNAPII localization changes d ...[more]