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Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.

ABSTRACT: RATIONALE:Obesity-related asthma is associated with higher disease burden than normal-weight asthma among Hispanics. Adiposity, metabolic dysregulation, and inflammation are all implicated in pathogenesis of obesity-related asthma, but their independent contributions are poorly understood. OBJECTIVE:To examine the independent contributions of body fat distribution, metabolic abnormalities and inflammation on asthma symptoms and pulmonary function among Hispanics. METHODS:Participants of the Hispanic Community Health Study/Study of Latinos with doctor-diagnosed asthma who completed an asthma symptom questionnaire and performed a valid spirometry were included in the analysis (n = 1126). Multivariate analysis was used to examine the independent association of general adiposity (assessed using body mass index), truncal adiposity (assessed by waist circumference), metabolic dysregulation (presence of insulin resistance and low HDL) and inflammation (high-sensitivity C-Reactive Protein?3 mg/L) with reported asthma symptoms or pulmonary function measures (FEV1, and FVC) while adjusting for demographic and clinical covariates. RESULTS:Of the 1126 participants, 334 (29.5%) were overweight, and 648 (57.8%) were obese. FEV1 and FVC were lower in obese compared to normal-weight asthmatics. In analyses controlling for metabolic and adiposity factors, high hs-CRP (>7 mg/L) was associated with more symptoms (prevalence-ratio 1.27 (95%CI 1.05, 1.54), and lower FVC (? -138 ml (95%CI -27 ml, -249 ml)) and FEV1 (? -155 ml (95% CI -38 ml, -272 ml). Low HDL was also associated with lower FVC (? -111 ml (-22 ml, -201 ml) and FEV1 (? -100 ml (-12 ml, -188 ml)). Results were similar in men and women. CONCLUSIONS:Our findings suggest that hs-CRP and low HDL, rather than general and truncal adiposity, are associated with asthma burden among overweight and obese Hispanic adults.

SUBMITTER: Rastogi D

PROVIDER: S-EPMC5395248 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.

Rastogi Deepa D Jung Molly M Strizich Garrett G Shaw Pamela A PA Davis Sonia M SM Klein Oana L OL Penedo Frank J FJ Ries Andrew L AL Daviglus Martha L ML Moreiras Juan J JJ Salathe Matthias A MA Celedón Juan C JC Isasi Carmen R CR Kaplan Robert C RC

Respiratory medicine 20170306

<h4>Rationale</h4>Obesity-related asthma is associated with higher disease burden than normal-weight asthma among Hispanics. Adiposity, metabolic dysregulation, and inflammation are all implicated in pathogenesis of obesity-related asthma, but their independent contributions are poorly understood.<h4>Objective</h4>To examine the independent contributions of body fat distribution, metabolic abnormalities and inflammation on asthma symptoms and pulmonary function among Hispanics.<h4>Methods</h4>Pa ...[more]

PMID: 28340865

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Project description:BackgroundInflammation and monocytes are thought to be important to human malaria pathogenesis. However, the relationship of inflammation and various monocyte functions to acute malaria, recovery from acute malaria, and asymptomatic parasitemia in endemic populations is poorly understood.MethodsWe evaluated plasma cytokine levels, monocyte subsets, monocyte functional responses, and monocyte inflammatory transcriptional profiles of 1- to 10-year-old Kenyan children at the time of presentation with acute uncomplicated malaria and at recovery 6 weeks later; these results were compared with analogous data from asymptomatic children and adults in the same community.ResultsAcute malaria was marked by elevated levels of proinflammatory and regulatory cytokines and expansion of the inflammatory "intermediate" monocyte subset that returned to levels of healthy asymptomatic children 6 weeks later. Monocytes displayed activated phenotypes during acute malaria, with changes in surface expression of markers important to innate and adaptive immunity. Functionally, acute malaria monocytes and monocytes from asymptomatic infected children had impaired phagocytosis of P. falciparum-infected erythrocytes relative to asymptomatic children with no blood-stage infection. Monocytes from both acute malaria and recovery time points displayed strong and equivalent cytokine responsiveness to innate immune agonists that were independent of infection status. Monocyte transcriptional profiles revealed regulated and balanced proinflammatory and antiinflammatory and altered phagocytosis gene expression patterns distinct from malaria-naive monocytes.ConclusionThese observations provide insights into monocyte functions and the innate immune response during uncomplicated malaria and suggest that asymptomatic parasitemia in children is not clinically benign.FundingSupport for this work was provided by NIH/National Institute of Allergy and Infectious Diseases (R01AI095192-05), the Burroughs Wellcome Fund/American Society of Tropical Medicine and Hygiene, and the Rainbow Babies & Children's Foundation.

Dataset Information

Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.

Publications

Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.

Similar Datasets

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