Ontology highlight
ABSTRACT:
SUBMITTER: Martin PM
PROVIDER: S-EPMC5395363 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Martin P-M PM Stanley R E RE Ross A P AP Freitas A E AE Moyer C E CE Brumback A C AC Iafrati J J Stapornwongkul K S KS Dominguez S S Kivimäe S S Mulligan K A KA Pirooznia M M McCombie W R WR Potash J B JB Zandi P P PP Purcell S M SM Sanders S J SJ Zuo Y Y Sohal V S VS Cheyette B N R BNR
Molecular psychiatry 20161018 2
Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals' brains have reduced dendritic spines and glutamatergic synapses. Treatment with lithium or a glycogen synthase kinase-3 (GSK3) inhibitor corrects behavioral and neurodevelopmental phenotypes in these animals. Analysis of DIXDC1 in over 9000 cases of autism, bipolar disorder and schizophrenia re ...[more]