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ABSTRACT: Objective
This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population.Method
This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters.Results
The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups.Conclusion
The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.
SUBMITTER: Nguimmo-Metsadjio A
PROVIDER: S-EPMC5395748 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nguimmo-Metsadjio Aurelie A Atogho-Tiedeu Barbara B Noubiap Jean Jacques JJ Evehe Marie-Solange MS Djokam-Dadjeu Rosine R Donfack Olivier Sontsa OS Nanfa Dieudonne D Mato Edith Pascale M EPM Ngwa Elvis Ndonwi EN Guewo-Fokeng Magellan M Pokam-Fosso Priscille P Mbacham Wilfred F WF Mbanya Jean Claude JC Sobngwi Eugene E
Journal of health, population, and nutrition 20170418 1
<h4>Objective</h4>This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population.<h4>Method</h4>This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment ...[more]