Ontology highlight
ABSTRACT:
SUBMITTER: Saygin C
PROVIDER: S-EPMC5395764 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Saygin Caner C Carraway Hetty E HE
Journal of hematology & oncology 20170418 1
Acute myeloid leukemia (AML) is characterized by clinical and biological heterogeneity. Despite the advances in our understanding of its pathobiology, the chemotherapy-directed management has remained largely unchanged in the past 40 years. However, various novel agents have demonstrated clinical activity, either as single agents (e.g., isocitrate dehydrogenase (IDH) inhibitors, vadastuximab) or in combination with standard induction/consolidation at diagnosis and with salvage regimens at relaps ...[more]