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Characterization of cyclophilin D in freshwater pearl mussel (Hyriopsis schlegelii).


ABSTRACT: Cyclophilin D (referred to as HsCypD) was obtained from the freshwater pearl mussel (Hyriopsis schlegelii). The full-length cDNA was 2 671 bp, encoding a protein consisting of 367 amino acids. HsCypD was determined to be a hydrophilic intracellular protein with 10 phosphorylation sites and four tetratricopeptide repeat (TPR) domains, but no signal peptide. The core sequence region YKGCIFHRIIKDFMVQGG is highly conserved in vertebrates and invertebrates. Phylogenetic tree analysis indicated that CypD from all species had a common origin, and HsCypD had the closest phylogenetic relationship with CypD from Lottia gigantea. The constitutive mRNA expression levels of HsCypD exhibited tissue-specific patterns, with the highest level detected in the intestines, followed by the gonads, and the lowest expression found in the hemocytes.

SUBMITTER: Liu XX 

PROVIDER: S-EPMC5396027 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Characterization of cyclophilin D in freshwater pearl mussel (<i>Hyriopsis schlegelii</i>).

Liu Xiu-Xiu XX   Wang Cheng-Yuan CY   Luo Chun C   Sheng Jun-Qing JQ   Wu Di D   Hu Bei-Juan BJ   Wang Jun-Hua JH   Hong Yi-Jiang YJ  

Zoological research 20170301 2


Cyclophilin D (referred to as <i>HsCypD</i>) was obtained from the freshwater pearl mussel (<i>Hyriopsis schlegelii</i>). The full-length cDNA was 2 671 bp, encoding a protein consisting of 367 amino acids. HsCypD was determined to be a hydrophilic intracellular protein with 10 phosphorylation sites and four tetratricopeptide repeat (TPR) domains, but no signal peptide. The core sequence region YKGCIFHRIIKDFMVQGG is highly conserved in vertebrates and invertebrates. Phylogenetic tree analysis in  ...[more]

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