Ontology highlight
ABSTRACT:
SUBMITTER: Yang XH
PROVIDER: S-EPMC5396509 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yang Xiao-Hui XH Yue Hai-Tao HT Yu Na N Li Yi-Pan YP Xie Jian-Hua JH Zhou Qi-Lin QL
Chemical science 20161115 3
We report a protocol for the highly efficient iridium-catalyzed asymmetric hydrogenation of racemic α-substituted lactones <i>via</i> dynamic kinetic resolution. Using Ir-SpiroPAP (<i>R</i>)-<b>1d</b> as a catalyst, a wide range of chiral diols were prepared in a high yield (80-95%) with a high enantioselectivity (up to 95% ee) under mild reaction conditions. This protocol was used for enantioselective syntheses of (-)-preclamol and a chiral 2,5-disubstituted tetrahydropyran. ...[more]