Ontology highlight
ABSTRACT:
SUBMITTER: Cesena D
PROVIDER: S-EPMC5397203 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Cesena Daniele D Cassani Corinne C Rizzo Emanuela E Lisby Michael M Bonetti Diego D Longhese Maria Pia MP
Nucleic acids research 20170401 7
Telomeric DNA consists of repetitive G-rich sequences that terminate with a 3΄-ended single stranded overhang (G-tail), which is important for telomere extension by telomerase. Several proteins, including the CST complex, are necessary to maintain telomere structure and length in both yeast and mammals. Emerging evidence indicates that RNA processing factors play critical, yet poorly understood, roles in telomere metabolism. Here, we show that the lack of the RNA processing proteins Xrn1 or Rrp6 ...[more]