Ontology highlight
ABSTRACT:
SUBMITTER: Minervini G
PROVIDER: S-EPMC5397843 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Minervini Giovanni G Lopreiato Raffaele R Bortolotto Raissa R Falconieri Antonella A Sartori Geppo G Tosatto Silvio C E SCE
Scientific reports 20170420
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor predisposes patients to develop different highly vascularized cancers. pVHL targets the hypoxia-inducible transcription factor (HIF-1α) for degradation, modulating the activation of various genes involved in hypoxia response. Hypoxia plays a relevant role in regulating cell cycle progression, inducing growth arrest in cells exposed to prolonged oxygen deprivation. However, the exact molecular details driving this transition ar ...[more]