Ontology highlight
ABSTRACT:
SUBMITTER: Muller CL
PROVIDER: S-EPMC5399236 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Muller Christopher L CL Anacker Allison Mj AM Rogers Tiffany D TD Goeden Nick N Keller Elizabeth H EH Forsberg C Gunnar CG Kerr Travis M TM Wender Carly LA C Anderson George M GM Stanwood Gregg D GD Blakely Randy D RD Bonnin Alexandre A Veenstra-VanderWeele Jeremy J
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20160823 2
Biomarker, neuroimaging, and genetic findings implicate the serotonin transporter (SERT) in autism spectrum disorder (ASD). Previously, we found that adult male mice expressing the autism-associated SERT Ala56 variant have altered central serotonin (5-HT) system function, as well as elevated peripheral blood 5-HT levels. Early in gestation, before midbrain 5-HT projections have reached the cortex, peripheral sources supply 5-HT to the forebrain, suggesting that altered maternal or placenta 5-HT ...[more]