Ontology highlight
ABSTRACT:
SUBMITTER: Marshall AG
PROVIDER: S-EPMC5399611 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Marshall Andrew G AG Lee-Kubli Corinne C Azmi Shazli S Zhang Michael M Ferdousi Maryam M Mixcoatl-Zecuatl Teresa T Petropoulos Ioannis N IN Ponirakis Georgios G Fineman Mark S MS Fadavi Hassan H Frizzi Katie K Tavakoli Mitra M Jeziorska Maria M Jolivalt Corinne G CG Boulton Andrew J M AJM Efron Nathan N Calcutt Nigel A NA Malik Rayaz A RA
Diabetes 20170215 5
Impaired rate-dependent depression (RDD) of the Hoffman reflex is associated with reduced dorsal spinal cord potassium chloride cotransporter expression and impaired spinal γ-aminobutyric acid type A receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Im ...[more]