Ontology highlight
ABSTRACT:
SUBMITTER: Jayaraj ND
PROVIDER: S-EPMC5983349 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Jayaraj Nirupa D ND Bhattacharyya Bula J BJ Belmadani Abdelhak A AA Ren Dongjun D Rathwell Craig A CA Hackelberg Sandra S Hopkins Brittany E BE Gupta Herschel R HR Miller Richard J RJ Menichella Daniela M DM
The Journal of clinical investigation 20180423 6
Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown. We hypothesize that chemokine CXCL12/CXCR4 signaling is central to this mechanism, as we hav ...[more]