Ontology highlight
ABSTRACT:
SUBMITTER: Kalkan T
PROVIDER: S-EPMC5399622 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20170207 7
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency. Here, we examine the initial transition process. The ES cell population behaves asynchronously. We therefore exploited a short-half-life <i>Rex1::GFP</i> reporter to isolate cells either side of exit from naïve status. Extinction of ES cell identity in single cells is ...[more]