Ontology highlight
ABSTRACT:
SUBMITTER: Bittner S
PROVIDER: S-EPMC5400151 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Bittner Stefan S Ruck Tobias T Wiendl Heinz H Grauer Oliver M OM Meuth Sven G SG
Therapeutic advances in neurological disorders 20160902 1
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that is caused by an autoimmune response against central nervous system (CNS) structures. Traditionally considered a T-cell-mediated disorder, the contribution of B cells to the pathogenesis of MS has long been debated. Based on recent promising clinical results from CD20-depleting strategies by three therapeutic monoclonal antibodies in clinical phase II and III trials (rituximab, ocrelizumab and ofatumumab), targeting B ce ...[more]