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Cross-sectional study of virological failure and multinucleoside reverse transcriptase inhibitor resistance at 12 months of antiretroviral therapy in Western India.


ABSTRACT: The free antiretroviral therapy (ART) program in India has scaled up to register second largest number of people living with HIV/AIDS across the globe. To assess the effectiveness of current first-line regimen we estimated virological suppression on completion of 1 year of ART. The study describes the correlates of virological failure (VF) and multinucleoside reverse transcriptase inhibitor (NRTI) drug resistance mutations (DRMs).In this cross-sectional study conducted between June and August 2014, consecutive adults from 4 State sponsored ART clinics of western India were recruited for plasma viral load screening at 12?±?2 months of ART initiation. Individuals with plasma viral load >1000?copies/mL were selected for HIV drug resistance (HIVDR) genotyping. Logistic regression analyses were performed to assess factors associated with VF and multi-NRTI resistance mutations. Criteria adopted for multi-NRTI resistance mutation were either presence of K65R or 3 or more thymidine analog mutations (TAMs) or presence of M184V along with 2 TAMs.Of the 844 study participants, virological suppression at 1 year was achieved in 87.7% of individuals. Factors significantly associated with VF (P?

SUBMITTER: Karade SK 

PROVIDER: S-EPMC5402603 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Cross-sectional study of virological failure and multinucleoside reverse transcriptase inhibitor resistance at 12 months of antiretroviral therapy in Western India.

Karade Santosh K SK   Ghate Manisha V MV   Chaturbhuj Devidas N DN   Kadam Dileep B DB   Shankar Subramanian S   Gaikwad Nitin N   Gurav Shraddha S   Joshi Rajneesh R   Sane Suvarna S SS   Kulkarni Smita S SS   Kurle Swarali N SN   Paranjape Ramesh S RS   Rewari Bharat B BB   Gangakhedkar Raman R RR  

Medicine 20160901 37


The free antiretroviral therapy (ART) program in India has scaled up to register second largest number of people living with HIV/AIDS across the globe. To assess the effectiveness of current first-line regimen we estimated virological suppression on completion of 1 year of ART. The study describes the correlates of virological failure (VF) and multinucleoside reverse transcriptase inhibitor (NRTI) drug resistance mutations (DRMs).In this cross-sectional study conducted between June and August 20  ...[more]

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