Ontology highlight
ABSTRACT:
SUBMITTER: Sok D
PROVIDER: S-EPMC5404394 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Sok Devin D Briney Bryan B Jardine Joseph G JG Kulp Daniel W DW Menis Sergey S Pauthner Matthias M Wood Andrew A Lee E-Chiang EC Le Khoa M KM Jones Meaghan M Ramos Alejandra A Kalyuzhniy Oleksandr O Adachi Yumiko Y Kubitz Michael M MacPherson Skye S Bradley Allan A Friedrich Glenn A GA Schief William R WR Burton Dennis R DR
Science (New York, N.Y.) 20160908 6307
A major obstacle to a broadly neutralizing antibody (bnAb)-based HIV vaccine is the activation of appropriate B cell precursors. Germline-targeting immunogens must be capable of priming rare bnAb precursors in the physiological setting. We tested the ability of the VRC01-class bnAb germline-targeting immunogen eOD-GT8 60mer (60-subunit self-assembling nanoparticle) to activate appropriate precursors in mice transgenic for human immunoglobulin (Ig) loci. Despite an average frequency of, at most, ...[more]